Anaphase-Promoting Complex-Cyclosome

An E3 ubiquitin ligase primarily involved in regulation of the metaphase-to-anaphase transition during MITOSIS through ubiquitination of specific CELL CYCLE PROTEINS. Enzyme activity is tightly regulated through subunits and cofactors, which modulate activation, inhibition, and substrate specificity. The anaphase-promoting complex, or APC-C, is also involved in tissue differentiation in the PLACENTA, CRYSTALLINE LENS, and SKELETAL MUSCLE, and in regulation of postmitotic NEURONAL PLASTICITY and excitability.

Also Known As:

Anaphase Promoting Complex

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Ligases: 5553
    - Ubiquitin-Protein Ligase Complexes
      - Ubiquitin-Protein Ligases: 3432
        Anaphase-Promoting Complex-Cyclosome: 127
Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Cell Cycle Proteins: 807
    - Anaphase-Promoting Complex-Cyclosome: 127

Kyla A Shea Selected Research

Kyla A Shea Research Topics

Disease

Drug/Important Bio-Agent (IBA)